What is the difference between Oxford cloth and nylon? Oxford cloth or nylon which is better?Oxford cloth and nylon are two different materials. Oxford cloth is a general term for fabrics, including polyester, nylon, cotton, acrylic, aramid, and so on.Nylon is a material, commonly known as nylon (Nylon), English name Polyamide, which is a general term for polymers containing amide groups in the repeating units of the main chain of macromolecules.So what is the difference between Oxford cloth and nylon? Which is better, Oxford cloth or nylon?